Menu
Menu
Clinical Trials
Home /
Clinical Trials
Clinical Trials mCRC
USA
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Interventional Oncology
|
TACE-Ax-HCQ
|
TACE Plus Axitinib and Hydroxychlorquine for Liver-Dominant Metastatic Colorectal Cancer (CRC) (TACE-Ax-HCQ)- Patients with liver dominant mCRC who have failed at least one line of systemic therapy receive 2 weeks of axitinib 5mg 2x day (BID) and HCQ 600 mg (BID) followed by lobar or segmental TACE monthly until entire tumor burden is treated, then continue axitinib/HCQ until progression or intolerable toxicity. Response and hepatic progression-free survival (HPFS) will be assessed one-month post-TACE, then every 3 months
|
|
|
Medical Oncology
|
SCOTI
|
Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late Line Metastatic Colorectal Cancer- Evaluate efficacy of TAS-OX alternating with TAS-IRI (sequential TASOXIRI) with Bevacizumab, in the treatment of mCRC. Phase II
|
|
|
Medical Oncology
|
|
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer- An open-label, single-arm, 2-stage, phase II study of cabozantinib in combination with nivolumab in patients with refractory metastatic CRC. Up to 46 evaluable patients will be treated with cabozantinib 40 mg orally daily in combination with nivolumab 480 mg IV every 28 days. One cycle is defined as 28 days.
|
|
|
Medical Oncology
|
SEAMARK
|
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer- A PHASE 2, RANDOMIZED, OPEN-LABEL STUDY OF ENCORAFENIB AND CETUXIMAB PLUS PEMBROLIZUMAB VERSUS PEMBROLIZUMAB ALONE IN PARTICIPANTS WITH PREVIOUSLY UNTREATED BRAF V600E-MUTANT, MSI H/DMMR METASTATIC COLORECTAL CANCER
|
|
|
Interventional oncology
|
ACCLAIM
|
Ablation With Confirmation of Colorectal Liver Metastases
|
|
|
Medical Oncology
|
|
ZN-c3 in Adult Participants With Metastatic Colorectal Cancer- A Phase 1/2, Open-Label, Multi-Center Study of ZN-c3 Administered in Combination With Encorafenib and Cetuximab in Adults With Metastatic Colorectal Cancer
|
|
|
Medical Oncology Surgical Oncology
|
|
DNX-2440 for Resectable Colorectal Liver Metastasis- A Phase I Safety and Window-of-opportunity Study of Preoperative Intratumoral Injection of OX40-ligand Expressing Oncolytic Adenovirus (DNX-2440) in Patients With Resectable Liver Metastasis
|
|
|
Medical Oncology Surgical Oncology
|
|
ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases
|
|
|
Radiation oncology
|
|
A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic
|
|
|
|
|
Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer
|
|
|
Medical Oncology
|
|
Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer- prospective phase II, single arm, single site trial will evaluate the efficacy of the combination of liposomal irinotecan (nal-IRI), TAS102, and bevacizumab for the treatment of patients with mismatch repair proficient, metastatic or unresectable colorectal cancer that has previously been treated with 5-fluorouracil, oxaliplatin, irinotecan and if RAS wild-type an anti-EGFR agent.
|
|
|
Medical Oncology
|
STIMVAX
|
Immunotherapy for Third Line Metastatic Colorectal Cancer- Phase IIB multi-site, open label study of a next generation immunotherapy for third-line MSI-S metastatic colorectal cancer using an "off-the-shelf", non-genetically manipulated living immune cell product (AlloStim) derived from the blood of healthy donors
|
|
|
Medical Oncology
|
|
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
|
|
|
Interventional oncology
|
|
Tissue Analysis After Thermal Ablation for Colon Cancer Liver Metastases Leading to Immediate Retreatment
|
|
|
Medical Oncology Surgical Oncology
|
|
Patient Outcomes After Hepatic Artery Infusion Pump Placement
|
|
|
Radiation Oncology Surgical Oncology
|
|
Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases
|
|
|
Surgical Oncology
|
|
Liver Transplantation for Unresectable Liver Limited Colorectal Metastases
|
|
|
Medical oncology
|
|
DNX-2440 for Resectable Colorectal Liver Metastasis
|
|
|
Radiation oncology
|
|
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
|
|
|
Medical oncology Surgical oncology
|
|
Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases
|
|
|
Radiation oncology
|
MOMENTUM
|
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
|
Canada
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
|
Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases
|
|
|
Medical oncology Surgical oncology
|
PERIOP-06
|
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
|
Brasil
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Radiation oncology
|
|
Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases
|
United Kingdom
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Medical oncology
|
|
Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases
|
|
|
Medical oncology
|
ACT
|
PS101-mediated ACT With Chemotherapy in Liver Metastases From Cancer of Gastrointestinal Origin
|
The Netherlands
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Medical oncology
|
CAIRO5
|
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases
|
|
|
Medical oncology Surgical oncology
|
CAIRO 6
|
Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for resectable colorectal peritoneal metastases: a multicentre, open-label, parallel-group, phase II-III, randomised superiority study
|
|
|
Interventional oncology
|
CAIRO 7
|
Radioembolization with 166Ho-microspheres in elderly and/or fragile patients with previously untreated unresectable liver-only metastases of colorectal cancer
|
|
|
Interventional oncology Surgical oncology
|
COLLISION
|
Colorectal liver metastases: surgery versus thermal ablation – a phase III single-blind prospective randomized controlled trial
|
|
|
Interventional oncology Radiation oncology
|
COLLISION-XL
|
Unresectable colorectal liver metastases: stereotactic body radiotherapy versus microwave ablation – a phase II prospective randomized controlled trial for CRLM 3-5 cm
|
|
|
Medical oncology Interventional oncology Surgical oncology
|
COLLISION RELAPSE
|
Recurrent Colorectal Liver Metastases: Repeat Local Treatment +/- Neoadjuvant Systemic Therapy - a Phase III Prospective Randomized Controlled Trial
|
|
|
Medical oncology
|
INTERACT-II
|
Intraperitoneal irinotecan with concomitant FOLFOX and bevacizumab for patients with unresectable colorectal peritoneal metastases – a phase II study
|
|
|
Medical oncology Interventional oncology Surgical oncology Radiation oncology
|
ORCHESTRA
|
A randomized multicenter clinical trial for patients with multi-ORgan, Colorectal cancer metastases comparing the combination of cHEmotherapy and maximal tumor debulking versuS chemoTheRapy Alone
|
|
|
Medical oncology
|
INTERACT-II
|
Intraperitoneal irinotecan with concomitant FOLFOX and bevacizumab for patients with
|
|
|
|
|
unresectable colorectal peritoneal metastases – a phase II study
|
|
|
Medical oncology Surgical oncology
|
PIPAC-II
|
Bidirectional treatment consisting of repetitive laparoscopic electrostatic pressurized intraperitoneal aerosol chemotherapy with oxaliplatin (ePIPAC-OX) and systemic intravenous chemotherapy for isolated unresectable colorectal peritoneal metastases: feasibility, safety, tolerability, and preliminary efficacy
|
|
|
Medical oncology Surgical oncology
|
PUMP-III
|
Adjuvant hepatic arterial infusion pump chemotherapy after repeat hepatectomy for patients with liver confined recurrence of colorectal cancer – a phase II study
|
|
|
Medical oncology Surgical oncology
|
PUMP-IT pilot
|
Hepatic arterial infusion PUMP chemotherapy combined with systemic chemoTherapy for potentially resectable colorectal liver metastases.
|
|
|
Medical oncology Surgical oncology
|
PUMP
|
Adjuvant hepatic arterial infusion pump chemotherapy after resection of colorectal liver metastases in patients with a low clinical risk score – a randomized controlled trial
|
|
|
Interventional oncology Surgical oncology
|
DRAGON 2
|
An International Multicenter Randomized Controlled Trial to Compare Combined Portal and Hepatic Vein Embolization (PVE/HVE) With PVE Alone in Patients With Colorectal Liver Cancer Metastases (CRLM) and a Small Future Liver Remnant (FLR)
|
Advertisement
Germany
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
ARMANI
|
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
|
|
|
Surgical oncology
|
LIVERT(W)OHEAL
|
Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorectal Liver Metastases
|
Denmark
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Radiation oncology Interventional oncology
|
|
Stereotactic Body Radiation Therapy vs. Microwave Ablation for Colorectal Cancer Patients With Metastatic Disease in the Liver
|
|
|
Interventional oncology
|
ISCOLIM
|
Improving Survival of COlorectal LIver Metastases by RFA-mediated Immunostimulation
|
|
|
Radiation oncology
|
SIRT
|
Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases
|
Norway
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Interventional oncology Surgical oncology
|
NEW-COMET
|
Ablation vs Resection of Colorectal Cancer Liver Metastases
|
|
|
Surgical oncology Medical oncology
|
SECAIII
|
Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer
|
|
|
Medical oncology Interventional oncology Surgical oncology
|
EXCALIBUR3
|
EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden
|
|
|
Surgical oncology
|
|
Liver Transplantation and Colorectal Cancer
|
|
|
Medical oncology
|
EXCALIBUR1+2
|
HAI-Floxuridine, or Liver-Tx, Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patients With Colorectal Liver Metastases and Heavy Tumour Burden
|
|
|
Surgical oncology
|
|
Partial Liver Segment 2/ 3 Transplantation Study
|
Sweden
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
SOULMATE
|
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
|
France
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
METALAP
|
Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases
|
|
|
Surgical oncology Interventional oncology
|
HYPER-LIV01
|
Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remnant
|
|
|
Medical oncology
|
CETIDYL
|
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/ RAF Metastatic Colorectal Cancer With Liver Metastases
|
|
|
Medical oncology
|
OSCAR
|
Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/ - Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver
|
Italy
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
RAPID-Padova
|
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases Resection And Partial Liver Segmental Transplantation With Delayed Total Hepatectomy
|
|
|
Surgical oncology
|
|
Liver Transplantation for Non-Resectable Colorectal Liver Metastasis
|
|
|
Surgical oncology
|
COLT
|
Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation
|
|
|
Surgical oncology
|
|
LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis (LIVERMORE)
|
Spain
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
TRASMETIR
|
Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases
|
|
|
Surgical oncology
|
|
Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research
|
|
|
Interventional oncology Medical oncology
|
LIVERPEARL
|
Chemoembolization (Lifepearls-Irinotecan) in Patients With Colorectal Cancer and Metastatic Disease
|
Australia
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Medical oncology
|
SYS-CAPLIOX
|
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
|
China
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Interventional oncology Surgical oncology
|
HELARC
|
Comparison of Hepatectomy and Local Ablation for Resectable Synchronous and Metachronous Colorectal Liver Metastasis
|
|
|
Surgical oncology
|
|
Minimally Invasive Versus Open Liver Resection for Patients With Colorectal Cancer Liver Metastases
|
|
|
Interventional oncology Medical oncology
|
|
The Safety and Efficacy of HAIC+Tislelizumab+Regorafenib in Patients With Colorectal Liver Metastases
|
|
|
Interventional oncology Medical oncology
|
|
Hepatic Arterial Infusion Chemotherapy Combined With Sintilimab and Regorafenib as Adjuvant Therapy for Colorectal Liver Metastasis Patients With a High Risk of Recurrent: a Single-arm, Phase II Study
|
|
|
Radiation oncology
|
HaRyPOT
|
High- and Low-dose Radiotherapy Combined With PD-1 Inhibitors for MSS CRLM
|
|
|
Medical Oncology
|
|
Exploratory Study on Combined Conversion Immunotherapy for Liver Metastasis of MSS Type Initial Unresectable Colorectal Cancer Based on Gene Status
|
|
|
Medical oncology
|
|
Conversion Therapy of RAS/ BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases
|
|
|
Radiation oncology
|
NRT-uCRLM
|
Yttrium-90 Carbon Microspheres in Patients With Unresectable Colorectal Liver Metastases
|
|
|
Medical oncology
|
|
Anti-CEA CAR-T Cells to Treat Colorectal Liver Metastases
|
|
|
Medical oncology
|
|
mFOLFOXIRI+Bev vs. mFOLFOX6+Bev for RAS Mutant Unresectable Colorectal Liver-limited Metastases
|
|
|
Medical Oncology
|
|
3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer With/ Without Liver Metastases
|
|
|
Medical oncology Interventional oncology
|
|
Phase II Study of Regorafenib and Toripalimab Combined With RFA in Patients With CRCLM
|
|
|
Medical oncology Interventional oncology
|
|
Cryoablation Combined With Sintilimab Plus Regorafenib In Previously Treated Colorectal Cancer Liver Metastasis
|
|
|
Medical oncology Interventional oncology
|
RIDER
|
Regorafenib Combined With Irinotecan Drug-Eluting Beads for Colorectal Cancer Liver Metastases
|
|
|
Medical oncology Interventional oncology
|
|
Systemic Chemotherapy Plus HAI(FUDR) vs Systemic Chemotherapy Alone For CRCLM
|
|
|
Medical oncology Radiation oncology
|
IMPROVE
|
Postoperative Chemotherapy With/ Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence
|
|
|
Medical oncology Interventional oncology
|
|
Hepatic Arterial Infusion Chemotherapy With Fruquintinib for Colorectal Cancer Liver Metastases As Third-line Therapy
|
|
|
Medical oncology
|
|
FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases
|
|
|
Radiation oncology
|
|
Curative Proton Beam Therapy for Patients With Liver Metastasis of Colorectal Cancer
|
|
|
Medical oncology
|
|
ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer
|
|
|
Medical oncology
|
|
Efficacy of Modified Fruquintinib in Colorectal Cancer Liver Metastases: A Phase II Study
|
|
|
Medical oncology Interventional oncology
|
|
Fruquintinib Combined With Tislelizumab and HAIC in Patients With Advanced Colorectal Liver Metastases Cancer Who Failed Standard Therapy
|
|
|
Medical oncology
|
|
TAS-102 Combined With Bevacizumab and Tislelizumab Third-line or Above in the Treatment of Liver Metastasis in Colorectal Cancer
|
|
|
Medical oncology Interventional oncology
|
|
A Study of Systemic Chemotherapy With/ Without HAI in Patients With Initially Unresectable Colorectal Liver Metastasis
|
|
|
Medical oncology
|
|
Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
|
Korea
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Surgical oncology
|
|
LT for Unresectable Colorectal Liver Metastasis
|
Vietnam
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Medical oncology
|
|
Surgery Outcome Treated by Neo-adjuvant Combination of Oxaliplatin, Irinotecan, Folinic Acid and Fluorouracil (FOLFOXIRI) Regimen in Synchronous Liver Limited Metastasis Colorectal Cancer
|
Singapore
|
Category
|
Trial acronym
|
Title
|
Link
|
|---|---|---|---|
|
Medical oncology
|
|
Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC
|
Want to View More Clinical Trials?
Recent Literature
- Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C. Treatment of Metastatic Colorectal Cancer: ASCO Guideline. J Clin Oncol. 2023 Jan 20;41(3):678-700. doi: 10.1200/JCO.22.01690. Epub 2022 Oct 17. PMID: 36252154; PMCID: PMC10506310.
- Waddell, J.J., Townsend, P.H., Collins, Z.S. et al. Liver-Directed Therapy for Metastatic Colon Cancer: Update. Curr Colorectal Cancer Rep 18, 18–25 (2022). https://doi.org/10.1007/s11888-022-00474-1
- Scarabel L, Bignucolo A, Toffoli G, Cecchin E, De Mattia E. Pharmacogenetics Role of Genetic Variants in Immune-Related Factors: A Systematic Review Focusing on mCRC. Pharmaceutics. 2022; 14(11):2468. https://doi.org/10.3390/pharmaceutics14112468
- Xiong F, Zhou YW, Hao YT, Wei GX, Chen XR, Qiu M. Combining Anti-epidermal Growth Factor Receptor (EGFR) Therapy with Immunotherapy in Metastatic Colorectal Cancer (mCRC). Expert Rev Gastroenterol Hepatol. 2023 Sep 13:1-8. doi: 10.1080/17474124.2023.2232718. Epub ahead of print. PMID: 37705376.
- Zhao J, Shi L, Ji M, Wu J, Wu C. The combination of systemic chemotherapy and local treatment may improve the survival of patients with unresectable metastatic colorectal cancer. Mol Clin Oncol. 2017 Jun;6(6):856-860. doi: 10.3892/mco.2017.1247. Epub 2017 May 8. PMID: 28588777; PMCID: PMC5451863.
- Arellano RS. What’s New in Percutaneous Ablative Strategies for Hepatocellular Carcinoma and Colorectal Hepatic Metastases? 2020 Update. Curr Oncol Rep. 2020 Jul 28;22(10):105. doi: 10.1007/s11912-020-00967-y. PMID: 32725433.
- Camacho JC, Petre EN, Sofocleous CT. Thermal Ablation of Metastatic Colon Cancer to the Liver. Semin Intervent Radiol. 2019 Oct;36(4):310-318. doi: 10.1055/s-0039-1698754. Epub 2019 Oct 31. PMID: 31680722; PMCID: PMC6823045.
- Alonso, J., Casans, I., González, F. et al. Economic evaluations of radioembolization with yttrium-90 microspheres in liver metastases of colorectal cancer: a systematic review. BMC Gastroenterol 23, 181 (2023). https://doi.org/10.1186/s12876-023-02793-5
- Entezari P, Gabr A, Salem R, Lewandowski RJ. Yttrium-90 for colorectal liver metastasis – the promising role of radiation segmentectomy as an alternative local cure. Int J Hyperthermia. 2022;39(1):620-626. doi: 10.1080/02656736.2021.1933215. PMID: 35465813.
- González-Flores E, Zambudio N, Pardo-Moreno P, Gonzalez-Astorga B, de la Rúa JR, Triviño-Ibáñez EM, Navarro P, Espinoza-Cámac N, Casado MÁ, Rodríguez-Fernández A. Recommendations for the management of yttrium-90 radioembolization in the treatment of patients with colorectal cancer liver metastases: a multidisciplinary review. Clin Transl Oncol. 2023 Sep 25. doi: 10.1007/s12094-023-03299-y. Epub ahead of print. PMID: 37747636.
