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Clinical Trials Breast Cancer
USA
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Category
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Trial acronym
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Title
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Link
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Medical Oncology
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NADiR
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A Phase II Study of NirAparib, Dostarlimab and Radiotherapy in Metastatic, PD-L1 Negative or Immunotherapy-Refractory Triple-Negative Breast Cancer
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Interventional Oncology
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COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients: A Prospective Observational Registry
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Medical Oncology
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NeoTAILOR: A Phase II Biomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer
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Medical Oncology
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TK IMPACT: Treatment Monitoring of Patients Receiving CDK 4/6 Inhibitors for Hormone Receptor (HR) Positive, HER2 Negative Metastatic Breast Cancer (MBC) With or Without the Addition of DiviTum® Serum Thymidine Kinase 1 (TK1) Activity Testing: Physician Decision Impact Study
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Interventional oncology Surgical oncology
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COOL-IT
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Cryoablation vs Lumpectomy in T1 Breast Cancers: A Randomized Controlled Trial With Safety Lead-in
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Interventional Oncology
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Characterizing Breast Masses Using an Integrative Framework of Machine Learning and Radiomics
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Medical Oncology
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A Randomized, Double-blind, Placebo-controlled Phase 3 Trial Testing Eftilagimod Alpha (Soluble LAG-3) in HER2-neg/Low Metastatic Breast Cancer Patients Receiving Paclitaxel, Following an Open-label Dose Optimization
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Medical Oncology
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Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells
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Radiation oncology
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Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer
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Interventional Oncology
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Focused Ultrasound With Low-Dose Gemcitabine to Augment Immune Control of Early Stage Breast Cancer
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Radiation Oncology Surgical Oncology
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NORDIS
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A Randomized Phase II Study Comparing Surgical Excision Versus Neoadjuvant Radiotherapy Followed by Delayed Surgical Excision of Ductal Carcinoma In Situ
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Canada
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Category
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Trial acronym
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Title
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Link
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Medical oncology
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Pharmacogenetic Dosing of Epirubicin in FEC Chemotherapy
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Brazil
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Category
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Trial acronym
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Title
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Link
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Radiation oncology
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HYPHEN
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Clinical Trial to Assess the Efficacy and Safety of Ultra_HYPofractionated RadiotHerapy in Women With BrEast CaNcer Receiving Regional Nodal Radiation vs Nodal Moderate Hypofractionated Radiotherapy
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China
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Category
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Trial acronym
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Title
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Link
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Interventional oncology
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A Single-center, Prospective Clinical Study of High-intensity Focused Ultrasound Tumor Treatment System(Super Knife) in the Treatment of Breast Cancer
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Medical oncology
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A Prospective, Open, Multicenter Single-arm Clinical Studie of Docetaxel, Carboplatin Combined With Inetetamab and Pyrotinib in the Treatment of Local-advanced HER2-positive Breast Cancer
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Medical oncology
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Palbociclib Combine With Endocrine Therapy and Anti-HER2 Therapy in HR Positive and HER2 Positive Advanced Breast Cancer
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Medical oncology
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A Prospective Study on Efficacy and Safety of Anlotinib Combined With Fulvestrant in Patients With HR-positive and HER2-negative, Secondary Endocrine-resistant, Locally Advanced or Metastatic Breast Cancer
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Medical oncology
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NACVCAC
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A Prospective Randomized Controlled Trail to Evaluate Efficacy and Safety of Sequential Neo-adjuvant Chemotherapy Plus Surgery Followed by Capecitabine Versus Conventional Postoperative Adjuvant Chemotherapy
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Radiation oncology Surgical Oncology
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BIRKIN
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A Prospective Study of Preoperative MRI Linac-based Tumor-bed Boost Followed by Breast-conservative Oncoplastic Surgery and Adjuvant Ultra-hypofractionated Whole Breast Radiotherapy for Early Stage Breast Cancer
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Medical oncology
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Effect of Neoadjuvant Radiation and Prediction of Response to Treatment in Locally Advanced Breast Cancer
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Medical oncology
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A Prospective, Multi-cohort, Exploratory Phase II Study of Trilaciclib Combined With Standard Chemotherapy in The Adjuvant Treatment of Hormone Receptor (HR) Negative Breast Cancer
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Medical oncology
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Circulating Tumor Cell Changes and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer: a Cohort Trial
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Radiation oncology Surgical oncology
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Phase II Study of Hypofractionated Post Mastectomy Radiation With Two-Stage Expander/Implant Reconstruction
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Medical oncology
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Efficacy and Safety of Pyrotinib Maleate Combined With ARX788 Neoadjuvant Treatment in Stage II-III HER2-positive Breast Cancer Patients Who Have Poor Outcomes After Treatment With Trastuzumab and Pertuzumab
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Surgical oncology
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Necrosis After Cold Dissection Versus Electrocautery Dissection in Endoscopic Nipple-Sparing Mastectomy and Immediate Implant-Based Reconstruction: A Prospective Randomized Controlled Trial
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Medical oncology
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A Phase I Multi-Center Study to Evaluate the Safety, Tolerability, and Efficacy of Chemotherapeutic Regiments in Surgical Patients With Infiltrating Ductal Carcinoma of Breast
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Spain
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Category
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Trial acronym
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Title
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Link
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Interventional oncology
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Radiofrequency Ablation in Breast Tumors in Early Stages
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Medical oncology
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A Phase Ib Study With a Safety lead-in Cohort and Expansion Phase, of the Safety, Tolerability, Biological Effect, and Efficacy of Allogenic Natural Killer Cells in Combination With Trastuzumab and Pertuzumab in Adult Patients With Refractory Metastatic Her2 Positive Breast Cancer
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Singapore
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Category
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Trial acronym
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Title
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Link
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Medical oncology
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START
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Phase I Dose Finding Study of Selinexor and Talazoparib in Patients With Advanced Refractory Solid Tumors, Followed by Phase II Expansion Cohort Study in Patients With Advanced/ Metastatic Triple Negative Breast Cancers
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United Kingdom
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Category
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Trial acronym
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Title
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Link
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Medical oncology
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PHOENIX
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PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition and/or Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Chemotherapy Resistant Residual Triple Negative Breast Cancer
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Korea
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Category
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Trial acronym
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Title
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Link
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Interventional oncology
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Comparison of Ultrasound and Breast MRI for Breast Cancer Detection Among Women With Dense Breasts and a Personal History of Breast Cancer
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Pubmed References:
- Zulkifli D, Manan HA, Yahya N, Hamid HA. The Applications of High-Intensity Focused Ultrasound (HIFU) Ablative Therapy in the Treatment of Primary Breast Cancer: A Systematic Review. Diagnostics (Basel). 2023 Aug 4;13(15):2595. doi: 10.3390/diagnostics13152595. PMID: 37568958; PMCID: PMC10417478.
- Zhu XQ, Lu P, Xu ZL, Zhou Q, Zhang J, Wang ZB, Wu F. Alterations in Immune Response Profile of Tumor-Draining Lymph Nodes after High-Intensity Focused Ultrasound Ablation of Breast Cancer Patients. Cells. 2021 Nov 29;10(12):3346. doi: 10.3390/cells10123346. PMID: 34943854; PMCID: PMC8699337.
- Zou Y, Liu B, Li L, Yin Q, Tang J, Jing Z, Huang X, Zhu X, Chi T. IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. Cancer Lett. 2022 Jan 1;524:121-130. doi: 10.1016/j.canlet.2021.10.016. Epub 2021 Oct 20. PMID: 34687790.
- Zwicker F, Klepper R, Hauswald H, Hoefel S, Raether L, Huber PE, Debus J, Schempp M. Helical Tomotherapy of Lymph Node-negative Early-stage Breast Cancer After Breast-conserving Surgery: Long-term Results. Anticancer Res. 2023 May;43(5):2041-2053. doi: 10.21873/anticanres.16365. PMID: 37097694.
- Zuo Z, Ye F, Liu Z, Huang J, Gong Y. MicroRNA-153 inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition in breast cancer via direct targeting of RUNX2. Exp Ther Med. 2019 Jun;17(6):4693-4702. doi: 10.3892/etm.2019.7470. Epub 2019 Apr 5. PMID: 31086603; PMCID: PMC6488978.
- Zhou X, Jiao D, Dou M, Zhang W, Lv L, Chen J, Li L, Wang L, Han X. Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression. J Cell Mol Med. 2020 Sep;24(18):10648-10662. doi: 10.1111/jcmm.15683. Epub 2020 Jul 28. PMID: 32725802; PMCID: PMC7521266.
- Zwartsen A, Chottanapund S, Kittakoop P, Navasumrit P, Ruchirawat M, Van Duursen MBM, Van den Berg M. Evaluation of anti-tumour properties of two depsidones – Unguinol and Aspergillusidone D – in triple-negative MDA-MB-231 breast tumour cells. Toxicol Rep. 2019 Oct 20;6:1216-1222. doi: 10.1016/j.toxrep.2019.10.012. PMID: 31788435; PMCID: PMC6880138.
- Keenan TE, Tolaney SM. Role of Immunotherapy in Triple-Negative Breast Cancer. J Natl Compr Canc Netw. 2020 Apr;18(4):479-489. doi: 10.6004/jnccn.2020.7554. PMID: 32259782.
- de Melo Gagliato D, Buzaid AC, Perez-Garcia J, Cortes J. Immunotherapy in Breast Cancer: Current Practice and Clinical Challenges. BioDrugs. 2020 Oct;34(5):611-623. doi: 10.1007/s40259-020-00436-9. PMID: 32870473.
- van de Voort EMF, Struik GM, Birnie E, Moelker A, Verhoef C, Klem TMAL. Thermal Ablation as an Alternative for Surgical Resection of Small (≤ 2 cm) Breast Cancers: A Meta-Analysis. Clin Breast Cancer. 2021 Dec;21(6):e715-e730. doi: 10.1016/j.clbc.2021.03.004. Epub 2021 Mar 17. PMID: 33840627.
- Zhou W, Yu M, Pan H, Qiu W, Wang H, Qian M, Che N, Zhang K, Mao X, Li L, Wang R, Xie H, Ling L, Zhao Y, Liu X, Wang C, Ding Q, Wang S. Microwave ablation induces Th1-type immune response with activation of ICOS pathway in early-stage breast cancer. J Immunother Cancer. 2021 Apr;9(4):e002343. doi: 10.1136/jitc-2021-002343. PMID: 33795388; PMCID: PMC8021888.
- Habrawi Z, Melkus MW, Khan S, Henderson J, Brandi L, Chu V, Layeequr Rahman R. Cryoablation: A promising non-operative therapy for low-risk breast cancer. Am J Surg. 2021 Jan;221(1):127-133. doi: 10.1016/j.amjsurg.2020.07.028. Epub 2020 Aug 1. PMID: 32788081.
